Curtis Callan

Role
Professor Emeritus
Office Phone
Assistant
Office
334 Jadwin Hall
Bio/Description

Curtis Callan is the James S. McDonnell Distinguished University Professor of Physics at Princeton University. He received his B.A. from Haverford College in 1961 and his Ph.D. in physics from Princeton in 1964. He has held numerous posts and positions prior to his appointment at Princeton, including assistant professor at Harvard University, visiting professor at the University of Paris, Gordon Moore Scholar at the California Institute of Technology, and visiting professor at the Institute for Advanced Study, among others. His research interests include quantum field theory, string theory, dissipative quantum mechanics and the quantum fracture of materials. More recently, his interests have shifted toward theoretical problems in cellular biology where he is involved in the design and analysis of novel experiments designed to answer unconventional, theoretically motivated, questions in biology. He is the recipient of numerous awards and honors, including the Sakurai Prize for Theoretical Particle Physics from the American Physical Society in 2000, and the Dirac Medal from the Abdus Salam International Center for Theoretical Physics in 2004. In addition, he is an elected Fellow of the Alfred P. Sloan Foundation, the American Physical Society, American Academy of Arts and Sciences, and is a member of the National Academy of Sciences. 

Selected Publications
  • "Statistical inference of the generation probability of T-cell receptors from sequence repertoires", with A. Murugan, T. Mora,  and A. Walczak, Proc. Natl. Acad. Sci. USA (2012) (to be published).
  • "Maximum entropy models for antibody diversity", with T. Mora, A. Walczak, and W. Bialek, Proc. Natl. Acad. Sci. USA 107 (2010) 5405-5410.
  • "Using deep sequencing to characterize the biophysical mechanism of a transcriptional regulatory sequence", with J. Kinney, A. Murugan and E. Cox, Proc. Natl. Acad. Sci. USA 107 (2010) 9158-9163.
  • "Energy-dependent fitness: a quantitative model for the evolution of yeast transcription factor binding sites", with J. Kinney, M. Laessig and V. Mustonen, Proc. Natl. Acad. Sci. USA 105 (2008) 12376-12381.
  • "Information capacity of genetic regulatory elements", with G. Tkacik and W. Bialek, Phys. Rev. E 78 (2008) 011910-011917.
  • "Information flow and optimization in transcriptional control", with G. Tkacik and W. Bialek, Proc. Natl. Acad. Sci. USA 105 (2008)12265-12270.
  • "Precise physical models of protein-DNA interaction from high-throughput data",
    with J. Kinney and G. Tkacik, Proc. Natl. Acad. Sci. USA 104 (2007) 501.