We consider supersymmetric twist and omega deformation of a type IIB brane setup involving N D3 and K D5 branes. In the large N limit, this leads to a holographic duality between two topological/holomorphic theories. We compute certain operator algebras from both sides of this topological holographic duality and find the result consistent with the claimed duality. The algebra we compute is the Yangian of gl_K, which is the symmetry algebra of an integrable spin chain. In addition, the instance of topological holography that we find is an example supporting Costello's proposal relating holography and Koszul duality.