Abstract: The convergence of gravitational wave astrophysics, large scale astronomical surveys, deep learning and large scale computing provide an emergent paradigm to fully realize Multi-Messenger Astrophysics. I will present recent results of this program at the interface of numerical relativity and deep learning to increase the depth and speed of gravitational wave discovery, and will provide a vision to unify this effort with real-time electromagnetic and astro-particle follow-up observations.